NFKB1 and familial pancreatic carcinoma: Genistein is a specific PTKinhibitor as well as an inhibitor of topoisomerase II, and may modulate TGF-βsignal transduction [11, 12].Interestingly, both genistein and DIM are known to inhibit NFkB inbreast, prostate, and pancreatic cancer cells [13–15].