MCF-7 and MDA-MB-231 breast cancer cells andBG-1 ovarian cancer cells were treated with concentrations of genistein rangingfrom 1–100 μM (at aconstant final DMSO concentration) for 24 hours, after which time CXCR4 andCXCL12 mRNAs were quantified by real-time PCR.CXCR4 mRNA levels were significantly decreased at 1 μM genistein in allthree cell lines (Figures 1(a)–1(c)). The gene discussed is CXCR4; the disease is ovarian carcinoma.