PPARG and lipodystrophy: Although these studies used a somewhat simplistic model of HIV-1 exposure, given theevidence of the impact of PPARγ on normal bone biology, and the observationthat it can be perturbed in HIV-1-associated lipodystrophy, it is tempting tointerpret these results as being suggestive of PPARγ playing a role in HIV-1-mediatedbone disease.