PPARG and HIV-1 infection: The importance of PPARγ in both bone and fat metabolism hasbeen clearly demonstrated, and while a role for PPARγ in the lipid abnormalities associated with HIV-1 and its treatment isemerging, its involvement in HIV-1-associated bone disease remains unclear.Given the common origin of both adipocytes and osteoblasts from mesenchymalstem cell, and the demonstrated effect of increased PPARγ expression on bone in vitroand in vivo, we hypothesize apotential role for PPARγ in the reduced bone mass associatedwith HIV-1 infection and treatment.