Electron microscopy has revealed a fibrillar morphology of the SOD1 aggregates found in motor neurons of FALS patients [6], in COS cells expressing mutant but not wild-type (WT) SOD1 [7], in neuroblastoma cells expressing ALS mutant SOD1 which were subjected to endoplasmic reticulum stress [8], and in transgenic mice expressing ALS mutant SOD1 [6], [9], [10]. The gene discussed is SOD1; the disease is neuroblastoma.