SOD1 and amyotrophic lateral sclerosis: While disulfide-linked SOD1 aggregates have been found in transgenic mice expressing ALS-related mutant SOD1 [49]–[50], and while there is some evidence that intermolecular disulfide formation plays a major role in SOD1 aggregation in transfected cultured cells [51]–[52], other work has shown that transfected cells expressing SOD1 variants lacking cysteine also develop SOD1 aggregates [42], [53], [54].