Repressors that operateduring the acute stage of infection are likely to include riboregulators encoded bythe latency associated transcript locus (LAT) [94]–[96].Expression of the LAT locus is required for ∼65% of the latentinfections established [27],[79], and in the absenceof LAT transcription, half of the neurons destined to be latently infected enter thelytic pathway and die [27]. The gene discussed is LAT; the disease is infection.