For example, treatment with betulinic acid resulted in upregulation of the pro-apoptotic Bcl-2 family protein Bax in neuroblastoma, glioblastoma and melanoma cells, whereas Bcl-XS was found at elevated levels in betulinic acid-treated neuroblastoma cells [12, 14, 16]. The gene discussed is BCL2; the disease is neuroblastoma.