UNC-45 and CDC-48 have been shown to interact in human cell culture lines and CDC-48 has been implicated in inclusion-body myopathy associated with Paget disease of bone and frontotemporal dementia (IBMPFD) [39] suggesting that chaperones like UNC-45 may also play a significant role in muscle related illnesses. This evidence concerns the gene UNC45B and frontotemporal dementia.