TLR9 and systemic lupus erythematosus: In vivo studies in systemic lupus erythematosus (SLE) mouse models demonstrate an essential role for TLR7 in the generation of RNA-containing antinuclear antibodies and deposition of pathogenic immune complexes in the kidney, with TLR7 recognizing RNA- and DNA-containing autoimmune complexes and TLR9 amplifying the autoimmune response [170].