Transgenic analysis of TLR7 determined that a modest increase in TLR7 expression resulted in spontaneous development of autoimmunity and a substantial increase in TLR7 expression caused fatal acute inflammation and profound DC dysregulation, indicating that TLR7 must be tightly regulated in order to prevent spontaneous triggering of harmful autoreactive and inflammatory responses [171]. This evidence concerns the gene TLR7 and Autoimmunity.