Comparative studies demonstrated that two i.n. doses (1 mg/kg/dose) of poly (ICLC) was more effective than two i.n. doses (100,000 U/kg/dose) of either recombinant mouse IFN-α or -γ in protection of mice against influenza A/PR/8/34 infection, with survival rates of 100% and 50%, respectively [32]. This evidence concerns the gene IFNA1 and infection.