Integration of papilliomaviruses into the host genome of cancer cells has been suggested to be one of the initial genetic events leading to metastasis [27], [34] and transfection of the oncoprotein E7 has been shown to trigger the early steps of the metastatic conversion in human keratinocytes via stimulation of the cyclin-dependant kinase inhibitor p27 and subsequent activation of the PI3K/Akt pathway [27]. The gene discussed is CDKN3; the disease is cancer.