TP53 and lung adenocarcinoma: We found that 12–24 hours treatment with 50 uM PRIMA-1MET induced nucleolar translocation of EBNA-5 in all cell lines such as the lymphoblastoid cells LSsp expressing virus encoded endogenous EBNA-5 (Figure 1) and transfected tumor cell lines such as the colon carcinoma line SW480 (endogenous mutant p53; Figure 2), the breast carcinoma line MCF7 (wt p53) and the lung adeno-carcinoma line H1299 (p53 null cells) as well as its transfected variant expressing mutant p53 (His175).