APOA4 and obesity due to melanocortin 4 receptor deficiency: Rhizoma Alismatis (A), Fructus Crataegi (B), Semen Coicis (C), Rhizoma Atractylodis Macroczphalae (D), Rhizoma Atractylodis (E) and Sclerotium Poriae Cocos (F), the herbs tradtionally used to treat obesity, were shown to activate ApoA-IV promoter activity in Caco-2/TC7 cells.