The present study shows that Radix Angelica Sinensis (I), Rhizoma Curcumae (J), Flos Chrysanthemi (K), Radix Notoginseng (L), Folium Nelumbinis (M) and Herba Taraxaci (N) increase ApoA-IV transcription and may also be used to treat obesity. Here, APOA4 is linked to obesity due to melanocortin 4 receptor deficiency.