APOA4 and obesity due to melanocortin 4 receptor deficiency: In the anti-obesity herb group, Rhizoma Alismatis (A), Fructus Crataegi (B), Semen Coicis (C), Rhizoma Atractylodis Macrocephalae (D) and Rhizoma Atractylodis (E) increased the ApoA-IV promoter activity by more than two folds (Figure 2).