In consequence, we are currently, in Gustave Roussy Institute, launching a phase II clinical trial in which metronomic dosage of cyclophosphamide followed by Dex vaccination (these Dex are produced from mature DC and harbor IL-15Rα and NKG2D ligands) are evaluated for the treatment of inoperable patients bearing stage IIIB/IV non-small cell lung cancer who responded or experienced disease stabilization after the first line chemotherapy. The gene discussed is IL15RA; the disease is non-small cell lung carcinoma.