At ∼3 weeks after tumor occurrence, the measurable tumor volumes were 5.5 and 2.8 fold higher in FVB/N male and female PyVT(+/−)/ADN(+/−) animals respectively than those of PyVT(+/−)/ADN(+/+) mice (Figure 3), whereas the differences for the implanted nude mice were approximately 3.2 and 2.1 fold for male and female tumor cells respectively (Figure 5). Here, CFD is linked to neoplasm.