Earlier, we have also reported that EGFR and VEGF overexpressions are frequent in cholangiocarcinoma (∼20 and 50%, respectively), that EGFR overexpression is an independent prognostic factor in IHCC, and that VEGF expression is associated with intrahepatic metastasis in IHCC (Yoshikawa et al, 2008). The gene discussed is VEGFA; the disease is cholangiocarcinoma.