Earlier, we have also reported that EGFR and VEGF overexpressions are frequent in cholangiocarcinoma (∼20 and 50%, respectively), that EGFR overexpression is an independent prognostic factor in IHCC, and that VEGF expression is associated with intrahepatic metastasis in IHCC (Yoshikawa et al, 2008). This evidence concerns the gene EGFR and cholangiocarcinoma.