NTRK1 and familial pancreatic carcinoma: Aberrant signalling by phosphatidylinositol-3-kinase (PI3K) is a prominent feature of pancreatic cancers, due to the high prevalence of abnormalities that regulate this pathway, including K-ras mutations that occur in approximately 90% of cases, increased expression of receptor tyrosine kinases like EGFR, and loss of PTEN (Korc, 1998; Ruggeri et al, 1998; Bardeesy and DePinho, 2002; Agbunag and Bar-Sagi, 2004; Asano et al, 2004; Chadha et al, 2006).