In particular, sensitive molecular approaches targeting TRBV28+TRBJ1-5+ cells bearing Glycine-Leucine-Glycine motif could be designed to immune-monitor Melan-A-specific responses in melanoma patients and to investigate whether the presence of this specific motif can provide prognostic information, contributing to the design of efficient anti-melanoma vaccines. This evidence concerns the gene TRBV28 and melanoma.