BCL2 and diffuse large B-cell lymphoma: (3) "Third, the cloning and characterization of the chromosomal breakpoints that are characteristic of follicular lymphomas, and some diffuse large B-cell lymphomas have shown a juxtaposition of the BCL2 oncogene to enhancer elements in the immunoglobulin heave-chain locus, resulting in deregulation of BCL2 [38]." An alternative explanation is that these chromosomal breakpoints occur after cancer initiation caused by disruption of morphostats and their frequency increases due to selection after the carcinogenesis process is underway.