A second line of evidence comes from identification of numerous mutations in the CaR gene identified from individuals suffering from three different genetic disorders, Familial Hypocalciuric Hypercalcemia (FHH), Neonatal Severe Hyperparathyroidism (NSHPT) and Autosomal Dominant Hypocalcemia (ADH). This evidence concerns the gene CASR and familial hypocalciuric hypercalcemia.