TRPV1 is associated with inducing inflammation and tissue damage in the pancreas, ileum and colon following dextran sulphate sodium-induced colitis in rats [90, 91], caerulein-induced pancreatitis [129], Clostridium difficile toxin A- and endocannabinoid-induced colitis [117, 118]. This evidence concerns the gene TRPV1 and colitis.