Furthermore, sensitization of TRPV1 by inflammatory mediators like prostaglandins (PGs) [108, 125], bradykinin (BK) [35, 138, 139], nerve growth factor (NGF) [35, 76, 161] and LOX metabolites of arachidonic acid [71, 73] may lead to exacerbation of asthma. Here, TRPV1 is linked to asthma.