Much earlier to the cloning of TRPV1, the hallmark agonist capsaicin has been traditionally in use for pain relief of peripheral origin in different disease settings like chemical or thermal hyperalgesia in neurogenic inflammation, herpes zoster, neuropathy, paresthetica, thoracotomy, mastectomy, amputation, and skin cancer [37, 64, 75, 206, 209]. This evidence concerns the gene TRPV1 and neuropathy.