CTCFL and head and neck squamous cell carcinoma: The lack of direct correlation of demethylation of promoter and increased expression in some of these targets (Figure 2) may simply be a reflection of the small cohort used to test this association in HNSCC, but may also be due to alternate mechanisms of transcriptional control of these genes other than promoter methylation status, including other promoters, repressors, or mediators (e.g. BORIS).