Of these targets, 9/18 showed demethylation (see Table 1) in tumor tissues in greater than 30% of the samples, including TKTL1 (4/10, p<0.05), H19 (6/10, p<0.05), MAGEA2 (5/10, p<0.05), MAGEA3/6 (5/10, p<0.05), MAGEA4 (5/10, p<0.05), MAGEA11 (5/10, p<0.05), GPR17 (3/10, p<0.10), GRIN1 (6/10, p<0.05), C19ORF28 (5/10, p<0.05), (chi-squared). The gene discussed is GRIN1; the disease is neoplasm.