Additionally, several cases of familial Beckwith-Wiedemann syndrome (BWS), with and without Wilms' tumors, have been shown to be caused by microdeletions of the methylation-specific CTCF binding sites in the H19 ICR, a rare familial cancer syndrome linked to epigenetics [39]–[41]. The gene discussed is CTCF; the disease is Beckwith-Wiedemann syndrome.