This pathway has been largely unexamined for associations with PD although IGF1 signaling is reported to have neuroprotective effects on dopaminergic neurons [32], [33] and it has recently been suggested that excessive IGF1 signaling accelerates ageing through deleteriously effects on protective mechanisms against proteotoxicity such as Lewy body formation in PD [34]. This evidence concerns the gene IGF1 and Parkinson disease.