Compared to ANG-1 and ANG-2 as biomarkers of CM, previously studied markers of severe and CM such as TNF (Figure 1B, Figure 2B, Table 3) had moderate accuracy as a discriminating test (Figure 1B, AUC: 0.834, p<0.001) in Thai adults; however, TNF was a poor discriminator between CM and uncomplicated malaria in the Ugandan pediatric population (Figure 2B, AUC: 0.557, p = 0.268). This evidence concerns the gene ANGPT2 and malaria.