The pathophysiology of obesity and type 2 diabetes mellitus is associated with abnormalities in endocrine signaling in adipose tissue and one of the key signaling affectors operative in these disorders is the nuclear hormone transcription factor peroxisome proliferator-activated receptor-γ (PPARγ) [1]–[4]. The gene discussed is PPARG; the disease is obesity due to melanocortin 4 receptor deficiency.