Although FHM associated with NLRP7 mutations is inherited in an autosomal recessive manner, in contrast to ZFP57 mutation, homozygotes have normal genomic methylation but in female homozygotes there is a failure to establish methylation imprints in their germ cells leading to hydatidiform moles and reproductive wastage (male homozygotes do not have imprinting defects in their sperm). The gene discussed is ZFP57; the disease is familial hemiplegic migraine.