For example, inactivation of ALK1 results in Hereditary Hemorrhagic Telangiectasia type 2 (HHT2) [12] and mutations of BMPR2 are found in primary pulmonary arterial hypertension patients [13] and pancreatic cancers [14]. The gene discussed is ACVRL1; the disease is telangiectasia, hereditary hemorrhagic, type 2.