NFKB1 and chronic obstructive pulmonary disease: The reported increase in NFκB induction and activation may be due to the presence of high levels of cytokines which prolong the lifespan of the neutrophil (eg. GM-CSF), the ability of IL-8 and IL-6 (both of which were significantly increased in COPD subjects) to suppress spontaneous apoptosis [46,47] or possibly due to viral and/or bacterial infection.