Increased expression of ApoE mRNA in IAD patients, along with other plasticity-related genes, such as growth-associated protein 43 (GAP-43), plasticity related gene (LPPR4), NRGN, synaptogyrin (SYNGR1) and beta-synuclein (SNCB) suggest a concerted response. This evidence concerns the gene SYNGR1 and internet addiction disorder.