Several inflammatory cells and their mediators, both of the innate and adaptive immune system, participate in the inflammatory response in COPD., Macrophages, neutrophils and CD8+ T cells are the cells usually considered the prime effector cells in pathogenesis of COPD [4], but recently DCs have been suggested to be a potentially important new player/orchestrator of the pattern of inflammation that characterizes of COPD [5]. Here, CD8A is linked to chronic obstructive pulmonary disease.