Since the initial studies showing the utility and feasibility of immunochemistry on paraffin-embedded formalin-fixed urological material (Fontana et al, 1987), Ki-67 was shown to be an interesting marker in prostate cancer at an early stage (Oomens et al, 1991; McLoughlin et al, 1993). The gene discussed is MKI67; the disease is Familial prostate cancer.