Others have described the importance of pre-replication proteins, especially Mcm2, as prognostic markers in dysplasias and neoplasia at various sites in the human body (Williams et al, 1998, 2004; Stoeber et al, 1999; Meng et al, 2001; Wharton et al, 2001; Alison et al, 2002; Going et al, 2002; Eward et al, 2004; Gonzalez et al, 2004; Dudderidge et al, 2005; Quaglia et al, 2006). This evidence concerns the gene MCM2 and neoplasm.