EGFR and neoplasm: If we consider the cases showing either Chr7 polysomy or EGFR gene amplification as a single group, we observed differences in eight patients (8 out of 36=22%), namely two cases with EGFR deregulation limited to primary tumour and six cases to the metastasis (κ=0.49, P=0.0002), thus revealing a moderate level of agreement between the two sites.