Table 1 shows the number of persons tested and cases diagnosed by age and stage. The mean age (s.d.)of diagnosis was 62.0 (4.9) years. Of the PSA-detected cancers, 87% were localised. In England, in the same period, 42 850 men, aged 50–69 years, were registered with clinically detected prostate cancer and 27% of the cases presented with advanced stage disease (ECRIC data; Table 1). This evidence concerns the gene KLK3 and prostate carcinoma.