We hypothesize, based on previously reported association of LXRA alleles with the metabolic syndrome and HDL levels, together with the lack of association with T2D and measures of glucose homeostasis reported here, that the impact of LXRA on susceptibility to the metabolic syndrome is mediated via an impact on lipid turnover rather than glucose homeostasis [12]. The gene discussed is NR1H3; the disease is type 2 diabetes mellitus.