TNF and Alzheimer disease: The cerebral microcirculation of AD patients releases a host of inflammatory proteins including thrombin, tumor necrosis factor-α (TNFα), transforming growth factor-β (TGFβ), interleukin (IL) IL-1β, IL-6, IL-8, macrophage inhibitory protein -1α (MIP-1α) and RANTES [8-11].