Conversely, both oligonucleotides containing either a mutated version of the control κB consensus sequence (Figure 5D, MT BC oligo) or a mutated sequence 5'-GCTCACGCCC-3' of the putative κB binding site of the P2-COMT promoter (Figure 5D, MT P2 oligo) had a minimal effect on TNFα-induced p65 binding. This evidence concerns the gene COMT and breast cancer.