Six of 529 (1.1%) patients with D28 ALT results had CTC grade 2 raised (>2.5 to 5 × ULN) ALT concentrations (range 104 to 196 IU per L) and one 2-year-old child (0.19%) in the AS+AQ group had asymptomatic, CTC grade 4 hepatitis [AST 1052, ALT 936 IU per L]). The gene discussed is GPT; the disease is Hepatitis.