The cell-extrinsic factors have known roles as inducers of endothelial cell growth (VEGF and ANGPTL4), inducers of lymphatic vessel growth (ADM) [60], and smooth muscle cell dynamics (GAL); thus, the expression of this gene set would appear to increase the likelihood of tumor survival by causing de novo vessel formation and providing a dual conduit for metastatic spread. This evidence concerns the gene VEGFA and neoplasm.