Two 'hypoxia signatures' have been described and shown to be of prognostic value across a variety of tumor types including breast [33,56]; the large signature of Chi et al [38] showed a four-gene overlap with the VEGF profile (ADM, NDRG1, DDIT4 and ANGPLT4) while the 'hypoxia-metagene' of Winter et al [56] showed a three-gene overlap (VEGF, NDRG1 and ANGPLT4); as might be expected, all three of these profiles were correlated (Table 5, p < 0.0001). This evidence concerns the gene ADM and neoplasm.