In addition, many other biologically important gene sets were identified, including an 'immediate early' gene cluster containing c-FOS and JUNB (Figure 2A) [43], a set of fibroblast genes containing PLAU, THSB2 and multiple collagen genes (Figure 2B), a set of immune cell genes (Figure 2D), and a gene set containing CXCL12 (Figure 2C); CXCL12 was the top-ranked gene from this SAM analysis and was recently identified as a chemokine whose high expression promotes tumor cell proliferation, migration and invasion [17]. This evidence concerns the gene PLAU and neoplasm.