CFL1 and breast carcinoma: Although it has been argued that cofilin may increase actin barbed ends not only through its severing activity [13], [45] but also by increasing the G-actin supply [23], the data (Fig. 7) demonstrate the crucial role of cofilin in stimulus-evoked lamellipod actin assembly, which is conserved between breast carcinoma cell lines and XTC fibroblasts.