Therefore, once the disease had been mapped to chromosome 1,15 a compelling candidate gene in the search area was the lamin A/C encoding gene (LMNA), which is a cause of Emery-Dreifuss syndrome, a form of muscular dystrophy associated with DCM and conduction defects, as well as a similar isolated heart disease.5 However, further high-resolution mapping placed LMNA outside the PFHBII-containing interval,15 and the search for the causative gene continues. This evidence concerns the gene LMNA and familial dilated cardiomyopathy.