ACE and hypertensive disorder: It took exactly 10 years (1995–2005) to show the supremacy of CCBs as first-choice drug in the therapy of hypertension, especially when combined with an ACE inhibitor.22 During those 10 years, I presented many articles and talks, trying to counter the Furberg hypothesis that CCBs are harmful, but none of my contributions were nearly as important as the very positive result of the ASCOT study which, unequivocally, showed the safety of CCB-based hypertension therapy.