Western blotting showed significant upregulation of endogenous FOXM1 protein in both premalignant (POE9n, D20) and HNSCC (CaLH2, CaDec12, UK1, 5PT) cell lines compared to normal oral keratinocytes (NHOK1, NHOK355; Fig 2D). The gene discussed is FOXM1; the disease is head and neck squamous cell carcinoma.