ADAMTS2 and Inguinal hernia: This further enabled us to select additional positional candidate genes from HSA5q35 potentially involved in human inguinal hernia [35], e.g. the collagen type XXIII, alpha 1 (COL23A1) and the ADAM metallopeptidase with thrombospondin type 1 motif, 2 (ADAMTS2), which likely map to the region surrounding 67 cM on SSC2 potentially linked to hernia susceptibility (Figure 1).