CYBB and neuroblastoma: In NOX2-siRNA PINK1 KD cells, the basal ROS production was significantly reduced compared to PINK1 KD cells treated with scrambled siRNA (from 315.6% ± 25.7% to 126.7% ± 9.4% of control, n = 96 control neuroblastoma cells; n = 92 for PINK1 KD; n = 127 for NOX2-siRNA PINK1 KD; Figure 6F).