Two such genes are the melanoma-specific oncogene MITF, which is selectively amplified and overexpressed in 20% of melanomas [97], and NKX2-1, which lies in the minimal amplified region of a lung-cancer-specific 14q13.3 amplicon found in up to 20% of lung cancers [98,99]. The gene discussed is NKX2-1; the disease is lung carcinoma.