GJA1 and neoplasm: This phenomenon is reversed in HuH7 hepatocellular carcinoma cells in which Cx43 enhanced tumor cell malignancy through inhibition of Cx32-mediated GJIC and suppression of Cx32 expression altogether [243], thus, concluding that the impact of GJIC on tumor metastasis may be dependent on the type of connexin expressed and the type of cells used.