ADAM33 and chronic obstructive pulmonary disease: We observed significant evidence (p value < 0.05) for association between 5 SNPs in ADAM33 (Q-1, rs6127096, p < 0.0028; S1, rs391839, p < 0.0025; S2, rs528557, p < 0.0326; V-1, rs543749, p < 0.0011 and V-4, rs2787094, p < 0.0068, Table 2) and the composite variable for COPD (FEV1/FVC ratio < 70% and ppFEV1 < 75%, Figure 1).