Interestingly, we noticed a significant association between the presence of anti-p46 antibodies and the reactivity against the peptide derived from α-enolase (P = 0.0047), between the presence of anti-p62 and reactivity against HSP60 peptide (P = 0.016), and between the presence of anti-p67 and reactivity against FUSE-BP2 peptide (P = 0.04), which confirms the identities of these polypeptides and may suggest that they could represent antigenic determinants recognized by RA autoAb. The gene discussed is IGFBP2; the disease is rheumatoid arthritis.