In an attempt to find a link between the response to therapy (yes/not), K-ras gene status (mutant/wild type) and the cytokine level (greater or lower than cut-off), we could only confirm the strong influence of K-ras gene status rather than the level of the four different cytokines in determining the therapy response of MM patients (data not shown). The gene discussed is KRAS; the disease is Miyoshi myopathy.