Similar to CTGF, CYR61 expression is also increased (~0.3 fold) in fetal sheep lungs undergoing accelerated growth [22] and abnormally high levels of CYR61 have been implicated in the pathogenesis of chronic obstructive pulmonary disease [26] in humans as well as lung injury in adult rodents induced by hyperoxia [25] or volutrauma [27]. This evidence concerns the gene CCN2 and chronic obstructive pulmonary disease.