For example, a number of markers around rs1326581 at 6p12.2 combined to provide relatively weak statistical evidence for increased homozygosity (only just exceeding the threshold of 15, Additional File 3 Table S7), yet these markers span PKHD1, the gene for polycystic kidney and hepatic disease, mutations in which are a known cause of autosomal recessive kidney disease (ARKD) which can result in stillbirth or death in infancy or childhood. Here, PKHD1 is linked to liver disorder.